Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient rein methadone hydrochloride tablets.

Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.

Don’t put this medication in your car’s glove compartment or leave it rein the car. Beryllium sure to avoid doing this when the weather is very hot or very cold.

Optimal methadone initiation and dose titration strategies for the treatment of pain have not been determined. Published equianalgesic conversion ratios between methadone and other opioids are imprecise, providing at best, only Artbestand averages that cannot Beryllium applied consistently to all patients. It should be noted that many commonly cited equianalgesia tables only present relative analgesic potencies of single opioid doses in non-tolerant patients, thus greatly underestimating methadone's analgesic potency, and its potential for adverse effects hinein repeated-dose settings.

For patients judged to Beryllium at risk, careful monitoring of cardiovascular Befindlichkeit, including QT prolongation and dysrhythmias and those described previously should be performed.

gemischt, um euphorisierende Wirkungen zu vermeiden → verhindert die Gefahr des schädlichen Opioidkonsums, wenn es injiziert statt oral eingenommen wird

Read the Patient Information that comes with methadone hydrochloride tablets before you take it and each time you get a new prescription.

Maintenance on a Stabilized Dose – During prolonged administration of methadone, as hinein a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. However, constipation and sweating often persist.

Didanosine and Stavudine – Experimental evidence demonstrated that methadone decreased the AUC and peak levels for didanosine and stavudine, with a more significant decrease for didanosine. Methadone disposition welches not substantially altered.

Beurteilung – Equianalgesic methadone dosing varies not only between patients, but also within the same patient, depending on baseline morphine (or other opioid) dose. Table 1 has been included rein order to illustrate this concept and to provide a safe starting point for opioid conversion. Methadone dosing should not Beryllium based solely on these tables. Methadone conversion and dose titration methods should always Beryllium individualized to account for the patient's prior opioid exposure, general medical condition, concomitant medication, and anticipated breakthrough medication use.

Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays hinein your body for a longer time. This raises your risk of side effects.

For people with a head injury: This drug may cause increased pressure hinein your brain. This can raise your risk of complications or cause death.

Methadone hydrochloride tablets can cause life-threatening breathing problems which can lead to death. These problems are more likely to happen when methadone hydrochloride tablets are first started or hinein someone World health organization is not already taking other narcotic (opioid) pain medicines.

More frequent Erhaltungstherapie mit Methadontabletten administration may be required during methadone initiation rein order to maintain adequate analgesia, and extreme caution is necessary to avoid overdosage, taking into account methadone's long elimination half-life.