The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Methadone produces a significant regression of sex accessory organs and testes of male mice and rats. Additional data have been published indicating that methadone treatment of male rats (once a day for three consecutive days) increased embryolethality and neonatal mortality. Examination of uterine contents of methadone-naive female mice bred to methadone-treated mice indicated that methadone treatment produced an increase in the Satz of preimplantation deaths rein all post-meiotic states.

For women who are breastfeeding: Methadone may pass into breast milk and may cause side effects in a child Weltgesundheitsorganisation is breastfed.

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Magnesiumsilikathydrat to your doctor about slowly stopping methadone hydrochloride tablets to avoid getting sick with withdrawal symptoms. Physical dependency is not the same as drug addiction.

Methadone treatment for analgesic therapy hinein patients with acute or chronic pain should only Beryllium initiated if the potential analgesic or palliative care benefit of treatment with methadone has been considered to outweigh the risk of QT prolongation that has been reported with high doses of methadone.

Bei beiden Varianten wird geklärt, welche Symptome der Patient hat, hinsichtlich lange sie schon andauern, welche Medikamente sonst noch eingenommen werden oder eingenommen worden sind zumal welcher Medikamentenwunsch besteht.

Addiction and misuse warning: Methadone comes with a risk of addiction even when it’s used the right way. This can lead to drug misuse. Having an addiction to and misusing this drug can increase your Erhaltungstherapie mit Methadontabletten risk of overdose and death.

Several studies have suggested that infants born to narcotic-addicted women treated with methadone during all or part of pregnancy have been found to have decreased fetal growth with reduced birth weight, length, and/or head circumference compared to controls.

Patients and their caregivers should Beryllium advised to discard unused methadone hinein such a way that individuals other than the patient for whom it was originally prescribed will not come in contact with the drug.

Methadone-maintained patients beginning treatment with CYP3A4 inducers should be monitored for evidence of withdrawal effects and methadone dose should Beryllium adjusted accordingly.

A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise. Respiratory depression is of particular concern hinein elderly or debilitated patients as well as in those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.

The following drug interactions were reported following coadministration of methadone with inducers of cytochrome P450 enzymes:

Methadone should Beryllium administered with particular caution to patients already at risk for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia). Careful monitoring is recommended when using methadone in patients with a history of cardiac conduction abnormalities, those taking medications affecting cardiac conduction, and rein other cases where history or physical exam suggest an increased risk of dysrhythmia. QT prolongation has also been reported hinein patients with no prior cardiac history Weltgesundheitsorganisation have received high doses of methadone.