Methadone contains methadone, a mu-agonist opioid with an abuse liability similar to other opioid agonists and is a Schedule II controlled substance. Methadone and other opioids used in analgesia have the potential for being abused and are subject to criminal diversion.

When treating pain, methadone given on a fixed-dose schedule may have a narrow therapeutic Stichwortverzeichnis rein certain patient populations, especially when combined with other drugs, and should Beryllium reserved for cases where the benefits of opioid analgesia with methadone outweigh the known potential risks of cardiac conduction abnormalities, respiratory depression, altered mental states and postural hypotension.

If you stop taking the drug suddenly or don’t take it at all: Your pain may not be controlled and you may go through opioid withdrawal. Symptoms of withdrawal include:

Opioide sind sowohl körpereigene denn selbst natürliche sowie synthetisch hergestellte Substanzen die an den Opioidrezeptoren wirken. Es handelt zigeunern im gange um eine morphinartige Tätigkeit, die direktemang zur Sucht fluorühren kann.

Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration.

Rein general, dose selection for elderly patients should Beryllium cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.

Increased side effects from both drugs: Taking methadone with certain medications raises your risk of side effects. This is because methadone and these other medications can cause the same side effects. As a result, these side effects can be increased. Examples of these drugs include:

are allergic to methadone or anything else hinein methadone hydrochloride tablets. Weiher the end of this leaflet for a complete Streich of ingredients.

Increased side effects from other drugs: Taking methadone with certain medications raises your risk of side effects from those drugs. Examples of these drugs include:

The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t be used hinein children younger than 18 years.

Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise. Respiratory depression is of particular concern hinein elderly or debilitated patients as well as in those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.

Patients seeking to discontinue methadone maintenance treatment of opioid dependence should be apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.

Additional animal data demonstrates Erhaltungstherapie mit Methadontabletten evidence for neurochemical changes rein the brains of methadone-treated offspring, including changes to the cholinergic, dopaminergic, noradrenergic and serotonergic systems. Additional studies demonstrated that methadone treatment of male rats for 21 to 32 days prior to mating with methadone-naive females did not produce any adverse effects, suggesting that prolonged methadone treatment of the male rat resulted in tolerance to the developmental toxicities noted in the progeny. Mechanistic studies hinein this rat model suggest that the developmental effects of “paternal” methadone on the progeny appear to Beryllium due to decreased testosterone production. These animal data mirror the reported clinical findings of decreased testosterone levels in human males on methadone maintenance therapy for opioid addiction and in males receiving chronic intraspinal opioids.